Latest update: April 21, 2025 - 4 minute read
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Best Saffron Supplement of 2025: A Buyers Guide
Find out which brands work and which to avoid.
AUTHOR'S NOTE: If you’re trying to find the best Saffron supplement online, look no further. We tested the top 5 brands. This article reveals why most saffron doesn't work, and which brand carries the #1 product of the year.
Why Do We Need Saffron?
Our modern lifestyle inflicts constant stress on our bodies. Both physically and mentally.
According to the National Institute of Health, many adults struggle with depressed mood and anxiety. And, it's only getting worse.
Unlike synthetic options, Saffron is a natural herb long used in Ayurvedic medicine to quiet the body's stress response and help brain activity.
Recent scientific studies have validated what ancient civilizations already knew: Saffron is trusted for its ability to reduce stress, improve cognitive function, and support mental clarity.
What Is Saffron?
Saffron is an adaptogen, which means it helps you adapt to stress.
It comes from the root and leaves of the Crocus sativus flower, a flower native to eastern and western Europe, the Middle East, and parts of Africa.
Traditionally, Saffron was consumed in the form of powders or in potions. However, modern advancements can now extract its beneficial compounds directly from the flower.
Benefits of High Quality Saffron
Supplements can be an effective and inexpensive method of improving your physical and mental health.
a Quality Saffron Supplement Can
Manage Stress
Calm Anxiety
Enhance Memory
Improve Focus
Support Vision
Support Sleep
Doses & Side Effects
The recommended dosage depends on several factors, including the purity and form of saffron.
The internet recommends 80-100+ mg per day...but that's not accurate, nor scientific - and potentially dangerous.
Most saffron on the market is garbage and has no quality control. They dry it, then sell it without any quality specification.
Instead I would refer to what scientific studies are revealing to be the optimal serving size.
30mg of saffron is the best dose according to reseach.
And, Saffr-Activ® is the leading saffron extract guaranteeing > 5% bioactive compounds (the active ingredients you want) so you know what you're ensuring the most results.
DIFFERENT FORMS OF saffron
Extract: The most consistent and potent option available. Typically found in gummy and caps. Be sure to buy only patented forms of extract. Saffr'Activ® is well studied.
Oils: Not for consumption. Saffron can be used as an essential oil for various purposes.
Spice: Saffron that is ground into small dust particles. Used in cooking and baking. The spice does not yield results like a supplement extract.
what to avoid
Extracts: Don't waste your money on extracts that aren't Saffr-Activ®
Bad Formulations: The science is clear. Look for no less than 30mg of Saffron extract.
AMZN-only Brands: Avoid these big marketplace brands. Most AMZ listings produced overseas with little oversight, no returns, and falsified customer feedback.
HOT TIP
When shopping for Saffron, consider this; select something you will enjoy taking daily. Your results rest firmly on your ability to take it every day for months at a time. Powdered saffron can add 30+ minutes to your daily routine!
TOP 5 SHOPPING MISTAKES
Sourcing Matters: Beware of non-patented, generic saffron with no quality control.
Cheap Saffron: The best saffron is more expensive per mg than most street DRVGS. Amzn is filled with garbage brands that drop-ship "Saffron" straight from China to your door. Don't buy saffron under $40 - it's not real.*
Lack of Lab Testing: Don't buy from brands that don't test for heavy metals, contaminants, and salmonella.
Top Saffron Supplements of 2025
Saffron Extract
Saffron
Extract
Saffr'Activ®
Saffr'Activ®
No Additives
No
Additives
Saffron Per Serving
Saffron Per Serving
Third Party Testing
Third Party
Testing
90 Day
Guarantee
90 Day Guarantee
FDA/GMP Registered
FDA/GMP
Registered
30 mg
30
mg
88.5mg
88.5
mg
44.25mg
44.25
mg
88.5 mg
88.5
mg
100 mg
100
mg
1: Chill Buttons
by Organics Ocean
Based on 4.9 Average Reviews
A+
RATING
90 Day Money Back Guarantee
PROS
30mg Saffr'Activ®
Great for stress, energy, and sleep
Organic Ashwagandha
Third Party Purity Tested
FDA and GMP Registered
90-Day Money-Back Guarantee
Fast Customer Care
Organic Sweetners
CONS
Sells Out Often
Only Available on Their Website
The Bottom Line
Organics Ocean went insane with "Chill Buttons" - and they're delicious!
This formula contains 30mg of Saffr'Activ® saffron, the patented, high-quality extract, along with 400mg of KSM-66 organic ashwagandha.
30mg is the EXACT dose used in all the studies supporting that saffron works...and 400mg is the same for the KSM-66 studies.
I love when brands do that...
SaffrActiv® is also the worlds most expensive spice, and valued more than gold per ounce, so Ocean definitely invested in their customers.
You can't buy this combination from big brands on Amzn, no way.
SaffrActiv® guarantees quality and traceability 100% by partnering with a local saffron harvester, where they grow the highest quality saffron in the world.
The flavor is a "lemonade" and has all organic sweeteners.
You just can't get anything better than this.
Tap the LEARN MORE button below and get 10% OFF. They have a 90-day money back guarantee so you have nothing to worry about.
2: Pure Saffron
by Pure Micronutrients
B
RATING
PROS
Saffron Extract
FDA Registered
Third Party Tested
CONS
Overly dosed
Unknown extract source
Rice flour additive
The Bottom Line
Saffron by Pure Encapsulations offers saffron in the form of caplets.
It's a generic extract so we were not able to identify the quality. So your results may vary depending on the batch you receive.
It contains 1 filler ingredient known as rice flour...my least favorite of all the additives.
3: Mood munchies
by Joyspring
B-
RATING
PROS
Saffron extract
Decent flavor
FDA and GMP Registered
CONS
Portioned for children
Non-Saffr'Activ
Excessive Additives
The Bottom Line
Joyspring offers 44.25mg of Saffron extract in their "Mood Munchies".
We included this on the list because they are popular on TikTok and their formulation is interesting.
The gummies taste decent and include some other minerals and herbs such as GABA and passion flower.
The main drawback is that these are for kids and the saffron is generic..customers may not get the results they would with a Saffr'Activ® product.
4: Saffron Extract
by Double Wood
C
RATING
PROS
Saffron Extract
GMP Certified
CONS
Non Organic
Overly dose
No Money Back Guarantee
The Bottom Line
These are saffron caps with a non-organic extract.
The Organics Ocean's #1 product contains Saffr'Activ, which costs a fortune to produce...
So a brand that can sell saffron at $20 brings quality concerns...
The lack of a return policy means it’s not the most risk-free choice either.
If you’re looking for a natural saffron supplement on a budget, this is worth a try—though if you’re dissatisfied, you won’t be able to send it back.
5: Saffron Blend
by Clean Nutraceuticals
C-
RATING
PROS
Affordable
Lab Tested
CONS
Overly dosed
Non-Saffr'Activ Extract
"Catch-all" supplement blend
Excessive additives
The Bottom Line
This is a popular AMZN brand. It is a "catch-all" supplement that includes a bunch of random vitamins and minerals.
It contains 100mg of generic saffron.
Be sure to do careful research on the other ingredients as all of these can cause various side effects in people. It may take time for you to know if your body will react to these added ingredients.
It's a decent price starting around $30, but this is generic saffron without the same quality control surrounding the percentage of active ingredients.
#1 Saffron Supplement of 2025
Chill Buttons
by Organics Ocean
Saffr'Activ® Saffron
90-Day 100% Guarantee
Third-Party Tested
Confirmed GMP Certified
KSM-66® Ashwagandha
Based on 4.7 Average Reviews
Tap to Get Our Promo Pricing
Our #1 Pick for Sea Moss
Wild Sea Moss
by Organics Ocean
References
DISCLAIMER: This scientific research is for informational purposes only. The results reported may not necessarily occur in all individuals. Rain Media provides this information as a service but does not endorse it. This information should not be read to recommend or endorse any specific products.
Akhondzadeh, S., et al. (2005). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial.
BMC Complementary and Alternative Medicine 5, 22.
Modabbernia, A., et al. (2012). Saffron in the treatment of patients with mild to moderate depression: A double-blind, randomized and placebo-controlled trial.
Journal of Affective Disorders, 136(3), 360–364.
Lopresti, A. L., et al. (2018). Efficacy of a standardised saffron extract (affron®) as an add-on to antidepressant medication in the treatment of persistent depressive symptoms in adults: A randomised, double-blind, placebo-controlled study.
Journal of Psychopharmacology, 32(5), 635–642.
Lopresti, A. L., et al. (2020). Effects of saffron on sleep quality in healthy adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled trial.
Journal of Clinical Sleep Medicine 16(6), 937–947.
Modabbernia, A., et al. (2012). Saffron in the treatment of fluoxetine-induced sexual dysfunction in women: A randomized double-blind placebo-controlled study.
Psychopharmacology 220(3), 751–758.
Agha-Hosseini, M., et al. (2008). Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: A double-blind, randomised and placebo-controlled trial.
BJOG: An International Journal of Obstetrics & Gynaecology 115(4), 515–519.
Safarinejad, M. R., et al. (2010). Saffron (Crocus sativus) and erectile dysfunction: A prospective, randomized, double-blind, placebo-controlled pilot study.
International Journal of Impotence Research 22(4), 240–250.
Kashani, L., et al. (2013). Saffron for treatment of fluoxetine-induced sexual dysfunction in women: Randomized double-blind placebo-controlled study.
Human Psychopharmacology: Clinical and Experimental 28(1), 54–60.
Lopresti, A. L., et al. (2018). affron®, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: A randomised, double-blind, placebo-controlled study.
Journal of Affective Disorders 232, 349–357.
Gout, B., et al. (2010). Satiereal, a Crocus sativus L. extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women.
Nutrition Research , 30(5), 305–313.
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This site and its products and services are not associated or affiliated with, nor endorsed by YouTube, Google, or related entities. They have not been reviewed or backed by YouTube or its affiliates. Causes of ailment or condition vary amongst individuals. It is important that each visitor perform due diligence before purchasing anything recommended by this site, and verify with the manufacturer any claim about the products or services they provide. Results mentioned in testimonials and references are real, but not typical. They are to be used as examples only. This site may contain affiliate links or other forms of compensation. [1] We have a financial relationship with some of our top picks and own the Organics Ocean brand.
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